Ahmadian Chashmi, N., Sharifi, M., Yousefzadi, M., Behmanesh, M., Rezadoost, H., Cardillo, A. and Palazon, J., 2013. Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss. Medicinal Chemistry Research, 22(2): 745-752.
- Cui, Q., Du, R., Liu, M. and Rong, L., 2020. Lignans and their derivatives from plants as antivirals. Molecules, 25(1): 1–17.
- Chen, E. G., Tsai, K. L., Chung, H. H. and Chen, J. T., 2018. Chromosome doubling-enhanced biomass and dihydrotanshinone I production in Salvia miltiorrhiza, a traditional Chinese medicinal plant. Molecules, 23(12): 3106.
- Dixit, V., Verma, S. and Chaudhary, B. R., 2015. Changes in ploidy and its effect on thymoquinone concentrations in Nigella sativa L. Seeds. Journal of Horticultural Science and Biotechnology, 90(5): 537-542.
- Doležel, J. and Bratoš, J., 2005. Plant DNA flow cytometry and estimation of nuclear genome size. Annals of botany, 95(1): 99-110.
- Glazier, D. S., 2021. Genome Size Covaries More Positively with Propagule Size than Adult Size : New Insights into an Old Problem. Biology, 10(4): 270.
- Gudej, J. and Tomczyk, M., 2004. Determination of Flavonoids, Tannins and Ellagic acid in leaves from Rubus L. species. Archives of Pharmacal Research, 27(11): 1114-1119.
- Harun, A., Cai, B., Yang, Z., Yang, Q., Ge, X. and Li, Z., 2021. Scientia Horticulturae Asymmetrical effects of autopolyploidization on organ size and gene expression in Brassica rapa and B. oleracea. Scientia Horticulturae, 282: 109991.
- Hemmati, S., 2007. Biosynthesis of lignans in plant species of the section Linum: pinoresinol-lariciresinol reductase and justicidin B 7-hydroxylase. Ph.D. Dissertation, Faculty of Mathematics and Natural Sciences ,University of Heinrich-Heine, Düsseldorf, 135 p.
- Hosseini, B. and Javanbakht, S., 2017. Effects of in vitro polyploidy induction on some morphological, physiological and biochemical traits of Salvia leriifolia Benth. Iranian Journal of Rangelands and Forests Plant Breeding and Genetic Research, 25(1): 24-42 (In Persian).
- Iannicelli, J., Guariniello, J., Tossi, V. E., Regalado, J. J., Di Ciaccio, L., Van Baren, C. M., Álvarez, S. P. and Escandón, A. S., 2020. The “polyploid effect” in the breeding of aromatic and medicinal species. Scientia Horticulturae, 260: 108854.
- Javadian, N., Karimzadeh, G., Sharifi, M., Moieni, A. and Behmanesh, M., 2017. In vitro polyploidy induction: changes in morphology, podophyllotoxin biosynthesis, and expression of the related genes in Linum album (Linaceae). Planta, 245(6): 1165–1178.
- Lalaleo, L., Alcazar, R., Palazon, J., Moyano, E., Cusido, R. M. and Bonfill, M., 2018. Comparing aryltetralin lignan accumulation patterns in four biotechnological systems of Linum album. Journal of Plant Physiology, 228: 197–207.
- Lavania, U.C., Srivastava, S., Lavania, S., Basu, S., Misra, N.K. and Mukai, Y., 2012. Autopolyploidy differentially influences body size in plants, but facilitates enhanced accumulation of secondary metabolites, causing increased cytosine methylation. The Plant Journal, 71(4): 539-549.
- Loureiro, J., Rodriguez, E., Doležel, J. and Santos, C., 2007. Two new nuclear isolation buffers for plant DNA flow cytometry: a test with 37 species. Annals of Botany, 100(4): 875-888.
- Lu, Z., Hou, M., Xu, R. and Zhang, X., 2021. Advances in research on metabolic pathways of podophyllotoxin in plants of Berberaceae. In IOP Conference Series: Earth and Environmental Science, 657(1): 012044.
- Mikac, S., Markulin, L., Drouet, S., Corbin, C., Tungmunnithum, D., Kiani, R., Kabra, A., Abbasi, B.H., Renouard, S., Bhambra, A. and Lainé, E., 2021. Bioproduction of anticancer podophyllotoxin and related aryltretralin-lignans in hairy root cultures of Linum flavum L. In: Ramawat KG, Ekiert HM, Goyal S (eds) Plant cell and tissue differentiation and secondary metabolites: fundamentals and applications. Springer Nature Switzerland, pp 503-540.
- Mishra, B. K., Pathak, S., Sharma, A., Trivedi, P. K. and Shukla, S., 2010. Modulated gene expression in newly synthesized autotetraploid of Papaver somniferum L. South African Journal of Botany, 76(3): 447-452.
- Murashige, T. and Skoog, F., 1962. A revised medium for rapid growth and bio assays with tobacco tissue cultures. Physiologia Plantarum, 15(3): 473-497.
- Osborn, T. C., Pires, J. C., Birchler, J. A., Auger, D. L., Chen, Z. J., Lee, H. S., Comai, L., Madlung, A., Doerge, R. W., Colot, V. and Martienssen, R. A., 2003. Understanding mechanisms of novel gene expression in polyploids. Trends in Genetics, 19(3): 141-147.
- Owen, R. W., Haubner, R., Mier, W., Giacosa, A., Hull, W. E., Spiegelhalder, B. and Bartsch, H., 2003. Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes. Food and Chemical Toxicology, 41(5): 703-717.
- Sabzehzari, M., Hoveidamanesh, S., Modarresi, M. and Mohammadi, V., 2019. Morphological, anatomical, physiological, and cytological studies in diploid and tetraploid plants of Plantago psyllium. Plant Cell, Tissue and Organ Culture, 139(1): 131-137.
- Sadat Noori, S.A., Norouzi, M., Karimzadeh, G., Shirkool, K. and Niazian, M., 2017. Effect of colchicine-induced polyploidy on morphological characteristics and essential oil composition of ajowan (Trachyspermum ammi L.). Plant Cell, Tissue and Organ Culture, 130(3): 543-551.
- Shah, Z., Gohar, U.F., Jamshed, I., Mushtaq, A., Mukhtar, H., Zia-UI-Haq, M., Toma, S.I., Manea, R., Moga, M. and Popovici, B., 2021. Podophyllotoxin : history , recent advances and future prospects. Biomolecules, 11(3): 603.
- Shariat, A. and Sefidkon, F., 2021. Tetraploid induction in savory (Satureja khuzistanica): cytological, morphological, phytochemical and physiological changes. Plant Cell, Tissue and Organ Culture , 146(1): 137-148.
- Singh, S., Kaur, I. and Kariyat, R., 2021. The multifunctional roles of polyphenols in plant-herbivore interactions. International Journal of Molecular Sciences, 22(3): 1–19.
- Smollny, T., Wichers, H., Kalenberg, S., Shahsavari, A., Petersen, M. and Alfermann, A.W., 1998. Accumulation of podophyllotoxin and related lignans in cell suspension cultures of Linum album. Phytochemistry, 48(6): 975-979.
- Tahsili, J., Sharifi, M., Safaie, N., Esmaeilzadeh-Bahabadi, S. and Behmanesh, M., 2014. Induction of lignans and phenolic compounds in cell culture of Linum album by culture filtrate of Fusarium graminearum. Journal of Plant Interactions, 9(1): 412–417.
- Tavan, M., Mirjalili, M. H. and Karimzadeh, G., 2015. In vitro polyploidy induction: changes in morphological, anatomical and phytochemical characteristics of Thymus persicus (Lamiaceae). Plant Cell, Tissue and Organ Culture, 122(3): 573–583.
- Tsai, Y. T., Chen, P. Y. and To, K. Y., 2021. Induction of polyploidy and metabolic profiling in the medicinal herb Wedelia chinensis. Plants, 10(6): 1232.
- Van Drunen, W. E. and Husband, B. C., 2018. Whole genome duplication decreases clonal stolon production and genet size in the wild strawberry Fragaria vesca. American Journal of Botany, 105(10): 1–13.
- Van Fürden, B., Humburg, A. and Fuss, E., 2005. Influence of methyl jasmonate on podophyllotoxin and 6-methoxypodophyllotoxin accumulation in Linum album cell suspension cultures. Plant Cell Reports, 24(5): 312-317.
- Wawrosch, C. and Zotchev, S. B., 2021. Production of bioactive plant secondary metabolites through in vitro technologies—status and outlook. Applied Microbiology and Biotechnology, 105(18): 6649–6668.
- Xia, J., Ma, Y. J., Wang, Y. and Wang, J. W., 2018. Deciphering transcriptome profiles of tetraploid Artemisia annua plants with high artemisinin content. Plant Physiology and Biochemistry, 130: 112–126.
- Xu, C.G., Tang, T.X., Chen, R., Liang, C.H., Liu, X.Y., Wu, C.L., Yang, Y.S., Yang, D.P. and Wu, H., 2014. A comparative study of bioactive secondary metabolite production in diploid and tetraploid Echinacea purpurea (L.) Moench. Plant Cell, Tissue and Organ Culture, 116(3): 323-332.
- Yousefzadi, M., Sharifi, M., Behmanesh, M., Ghasempour, A., Moyano, E. and Palazon, J., 2012. The effect of light on gene expression and podophyllotoxin biosynthesis in Linum album cell culture. Plant Physiology and Biochemistry, 56: 41–46.
- Yousefzadi, M., Sharifi, M., Chashmi, N. A., Behmanesh, M. and Ghasempour, A., 2010. Optimization of podophyllotoxin extraction method from Linum album cell cultures. Pharmaceutical Biology, 48(12): 1421–1425.
- Zare Teymoori, S., Karimzadeh, G. and Shariat, A., 2021. Chromosomal and genome size diversity in savory (Satureja spp.) medicinal plant. Iranian Journal of Rangelands and Forests Plant Breeding and Genetic Research, 29(2): 236- 250. (In Persian).
- Zhou, Y., Kang, L., Liao, S., Pan, Q., Ge, X. and Li, Z., 2015. Transcriptomic analysis reveals differential gene expressions for cell growth and functional secondary metabolites in induced autotetraploid of Chinese woad (Isatis indigotica Fort.). PLoS One, 10(3): e0116392.
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